[Structure and function of glomerular basement membrane].

نویسنده

  • Tatsuo Sakai
چکیده

The glomerular basement membrane (GBM) is thin extracellular matrices which separate the visceral epithelium of the glomerulus from the capillary endothelium and serves as a filter for blood molecules. GBMs are composed of type IV collagen, laminin, heparan sulfate proteoglycan, entactin/nidogen, fibronectin and other minor glycoproteins which are not characterized. Recent technological advances have been made in determing the protein and gene structure of these proteins. This article will review the current informations of GBM constituents, structure and function.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی اثرات مزمن کلرید آلومینیوم بر فراساختمان غشای پایه گلومرولی، مورفولوژی و مورفومتری بافت‌های کلیوی خرگوش

   Background & Aims: Aluminum has many harmful effects on biochemical and physiological structures even behavioral disorders. Materials & Methods: The rabbits were classified into treatment and control groups. 12.5mg/kg aluminum chloride was injected to treatment group animals and simultaneously the same dose of deionized water to control group animals in anesthesia state for 7 weeks, intraper...

متن کامل

Alport’s Syndrome: Ultra-structural Study of 26 Suspected Cases

Introduction and Objective: Alport’s syndrome (hereditary nephritis with deafness) is a familial uncommon disease that ultra-structural studies are gold standard method of its diagnosis. Materials and Methods:We studied 26 Iranian patients suspicious of Alport’s syndrome by electron microscopy. We examin...

متن کامل

Anti-Glomerular Basement Membrane Disease Accompanied by Membrano Proliferative Glomerulonephritis: A Case Report

Anti-glomerular basement membrane disease is characterized by autoimmunity to antigenic sites on type IV collagen of the glomerular basement membrane. The majority of patients present with rapidly progressive glomerulonephritis and alveolar hemorrhage. The occurrence of antiglomerular basement membrane disease and other types of glomerulonephritis, such as membranous nephropathy, IgA nephropath...

متن کامل

New insights into the molecular biology of the glomerular filtration barrier and associated disease.

The glomerular filtration barrier of the kidney can no longer be considered as an inert and adynamic structure, viewed by electron microscopy. Molecular biology, medical genetics and protein chemistry have enabled us to further understand the complex structure and function of this highly specialized barrier of the kidney. Minor aberrations of physiology can lead to fatal disease. Recent advance...

متن کامل

Basement membrane.

Basement membrane has attracted less attention than the other components of connective tissue. But, like the other extracellular fibres and matrix materials, it can profoundly influence both the structure and function of advanced life forms. Usually taking the shape of thin, structureless cementing material between epithelial and connective tissue, basement membranes are widely distributed thro...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Nihon rinsho. Japanese journal of clinical medicine

دوره 64 Suppl 2  شماره 

صفحات  -

تاریخ انتشار 2006